::Departments : Pre Clinical : BioChemistry
INSTITUTE OF BIOCHEMISTRY

SHORT HISTORY OF THE DEPARTMENT:
The Biochemistry Department, which used to be a part of the Physiology Department in all medical colleges in the past, became an independent Department in Madras Medical College only in the year 1925.
 
        Dr. A.S.Mannady Nair, M.B.B.S., Ph.D., was the first Professor of the Department of Biochemistry, and headed the Department for a long period of 24 years till 1949. It is of interest to note that he was the first and only Professor from the basic sciences (often called Non-clinical department) to become the Surgeon General (Head of Medical Services) of the Madras Presidency in the year 1949. The Post of Surgeon General later became the Director of Medical Services.

Incidentally, Madras Presidency included present-day Tamil Nadu, the Malabar region of North Kerala, Lakshadweep Islands, the Coastal Andhra and Rayalaseema regions of Andhra Pradesh, Brahmapur and Ganjam districts of Orissa and the Bellary, Dakshina Kannada, and Udupi districts of Karnataka with the capital at Madras (now known as Chennai).
     
      GROWTH & EXPANSION:
™    Dr. A.S. Ramachandran M.B.B.S., M.Sc., became the Professor in 1949 and continued till 1954.
™    Dr. NainanVerghese, M.B.B.S., M.Sc., Ph.D., held the post of Professor from 1954 to 1970.
™    Dr.AmbikaShanmugam, M.B.B.S. M.Sc., headed the department from 1970 to 1977. She authored one of the earliest books on Biochemistry for Medical Students titled ‘Fundamentals of Biochemistry for Medical Students’ which is still popular and prescribed by various universities and followed by medical, dental nursing and science students all over India. It is in its 10th edition now.
™    Dr. S.Gopalakrishnan M.B.B,S F.R.CS (Edin) became the Professor in 1977. It was due his untiring efforts that the Biochemistry Department was upgraded to the status of an Institute in the year 1984, of which he became the First Director and Professor which he held till 1987.
™    During his time, automation in clinical biochemistry laboratory was introduced for the first time in Madras Medical College &Govt .General Hospital with the installation of the Batch Analyser, Technicon, Atomic Absorption Spectrophotometer for trace element estimation, UV spectrophotometer, HPLC, flourimeter, micro cellulose acetate electrophoresis with densitometer, ABL blood gas analyzer full fledged research were taking place with the availability of the sophisticated equipments.
™    Dr. (Mrs.) SarojiniRajaram M.D, succeeded him in the year 1987 and she has the credit of the first Director with Post Graduate Degree in biochemistry (M.D. in biochemistry) and continued till 1989.
™    Dr. (Mrs) Padma Ramamurthy, M.B.B.S., M. Sc., took over as Director in 1990 till Dr. L.Suryakurnari M.D., took over in 1994 and headed the headed  the Institute till 1998. It was during her period all manual enzyme assays were shifted to semi automation with the installation of ERBA CHEM semi auto analyser .
™    Dr. AnandiAlagappan, M.D..succeeded her in 1999 and held the  post of Director between March 1999 & August 2000   .
™    Dr. W.Ebenezer William, M.D., occupied the post of Director from February 2001 to January 2003,It was he who designed the present central clinical biochemistry lab in the ground floor of tower block  and was instrumental in installing the first ISE NOVA electrolyte analyzer followed by another electrolyte analyser in the next year. It was also during his tenure that centralizing the sample collection services of Govt. General Hospital was planned.
™    It was during the tenure of Dr.T.S. Andal from 2003 to 2006 that the biochemistry lab was shifted to its present location in the ground floor of tower block I from the college side and the first Random Access Biochemistry Analyser XL 300 with a throughput of 300 tests per hour was installed.
™    Dr.A.Manamalli M.D., took over as Director in June 2006 and continued till September 2007. During her tenure, the erstwhile famous FTM room (Fractional Test Meal Room where the test to assess gastric acid output used to be measured in the biochemistry department in those days!!)  was converted into a modern air- conditioned seminar hall with 108 seats .Shewas also instrumental in fully equipping the clinical biochemistry laboratory with the 2nd Automated Random Access Biochemistry Analyser (XL 300), Automated ELISA System (Triturus), Automated Coagulation Analyser (CA1500, CA 50), Automated Electrophoresis system (Sebia).
™    Dr.A.Renuka, M.D., M.N.A.M.S., Ph.D., became the Director in January 2008 which she held till October 2008.It was during her time, seeds were sown for the molecular diagnostics laboratory with planning and design of the molecular biology lab and purchase of Thermal Cycler, Refrigerated micro centrifuge, UV gel documentation system laminar air flow chamber for molecular biology related work.
™    Dr.Pragna B. Dolia, M.D., took over as Director in 2009 and continued until her retirement in 2012. It was during this period maximum number of CME and workshop were organized and conducted in this department.
™    Dr.R.Nagendran, M.D., held the post of Director during April 2014.
™    Dr.K.Ramadevi, M.D.,Ph.D., took over as Director from November 2014 and continuing till date. Complete modernization of the clinical diagnostic laboratory was effected with sophisticated high end diagnostic services including integrated automated analyzers for chemistries, immunoassays, capillary electrophoresis, immunotyping and immunofixation electrophoresis. Laboratory information system was installed with all equipments interfaced, reducing turn around time and minimizing errors. The lab Statistics has doubled and has reached a whooping 2509415 by 2017.
TIME LINE & MILESTONES OF THE INSTITUTE
v    1925 – Biochemistry became an independent department
v    1966 – Starting of M.D. Biochemistry Course
v    1984      -Upgradation of Biochemistry Department as an Institute with Director as its head Dr.S.Goplakrishnan becomes the first Director.
v    1997 –installation of first ISE Electrolyte analyzer and semi automated analyzer for enzyme assays (ERBACHEM 5)
v    2003 –Installation of first random Access Fully automated clinical chemistry analyzer (XL 300)
v    2003 - Shifting of biochemistry lab to the new tower block
v    2007 -Installation of first automated ELISA system (Triturus).
v    2007 - Installation of first automated coagulation analyzer
v    2007 - Installation of automated electrophoresis system with scanner (Sebia Hydrasys) Installation of second random Access Fully automated clinical chemistry analyzer (XL 300)
v    2015 -Installation of Integreted Random Access Fully Automated Clinical Chemistry and ImmunoAnalyser (Cobas6000) and AU480.
v    2016- ICH: HPLC system for Hemoglobinopathies.
v    2017- Capillary electrophoresis(Sebia Capillary’s 2; minicap),Automated agarose gel electrophoresis (Hydrasys-Sebia),Chemiluminescence gel documentation system
v    2017-ICH: Tandem mass spectrophotometry for New born screening, Capillary electrophoresis for HbA1C, Automated Clinical Chemistry and ImmunoAnalyser by eCLIA.
 
ACADEMIC ACTIVITES:
 
Type of course:  Medical PG Course
 
§      Name of the courses offered: M.D. (Biochemistry)
§      Eligibility: M.B.B.S. Degree from any Indian university recognized by the Medical Council of India & and obtained permanent registration from any of the State Medical Councils.
§      Course duration: 3 years
§      Sanctioned number of seats: 4 students per year
§      Affiliated University: The Tamil Nadu DR. M.G.R Medical University, Chennai.
§      Selection Procedure: Post Graduate Entrance Examination All India & State.
§      University Examination details:
Theory:    The Post Graduate students write 4 theory papers each of 100 Marks and of 3 hours duration (Total 400 marks) at the end of the 3rd year. 
Paper I: Physical and Organic Aspects of Biochemistry, Instrumentation Biochemical       
             Techniques, biostatistics and research methodology.
Paper II :Cell Physiology, Molecular Biology and Human Genetics
Paper III: Intermediary Metabolism, Macro and Micro Nutrients and Inborn Errors of
              Metabolism
 Paper IV: Clinical Biochemistry, Human Nutrition, Endocrinology, Immunology and
                Recent Advances in Biochemistry
Question Paper Pattern:   PAPER I, II, III & IV:
 Structured Essay Questions            - 2 x 15 Marks  = 30 Marks
 Short Notes                          -  10 x 5 Marks = 50 Marks 
 Reasoning out                        -  4  x 5 Marks = 20 Marks                                                                                     
                                                         -------------
                                                               100 Marks
                                                   -------------
PRACTICAL EXAMINATION AT THE END OF THE TRAINING PROGRAMME:
The practical examinations will be held over 2 days. It will have the following components:
MD BIOCHEMISTRY
PART I – 80 MARKS
A  Clinical case presentation and discussion       40 marks
B Estimation of 2 analytes 40 marks
PART II- 120  MARKS
A Preparation of a standard graph for one analyte 20 marks
B  Clinical cases –  4 charts -  Discussion                20 marks
 C Chromatography 30 marks
D Serum Protein electrophoresis 30 marks
  OSPE – 4 stations x 5 marks 20 marks
VIVA VOCE
  PEDAGOGY 40 marks
  VIVA 60 Marks
AGGREGATE (Clinical +Viva)             300 MARKS
Minimum required for pass  (50%)        150 MARKS
DISSERTATION             -       APPROVED / NOT APPROVED
 
The practical examinations shall consist of the following components, which will be held over 2 days
 
MD BIOCHEMISTRY
Part – I Clinical case presentation and
discussion - 40 marks
Clinical case presentation and discussion.
To plan relevant investigations
Estimation of 2 analytes
2x 20 =40 marks
Assay of 2 biochemical analytes
relevant tothe case under discussion.
One assay is tobe an end-point assay
and another is to be a kinetic assay.
Part – II
 
A. Preparation of a standard
graph for one analyte – 20 marks
Preparation of a standard graph for an analyte (preferably an analyte already allotted in Part I above ,i.e if Glucose assay is included in part I, standard graph for the same to be done)
B. Clinical cases – 4 charts - 4 x 5 marks = 20 marks Discussion of findings and lab results
of case scenarios provided
C. Chromatography - 30 marks Identification of the unknown
carbohydrate/aminoacid
D. Serum Protein electrophoresis 30 marks Serum Protein electrophoresis by
agarose gel electrophoresis and
interpretation.
OSPE – 4 stations x 5 marks = 20 marks Two performance stations and
response stations(Examples of
performance stations: methylamine
test for detecting fructose,
mucic acid test for detecting
galactose, Neumann’s test, Watson-
Schwartz test,etc) ,(Examples of
response stations: Levy Jennings
chart, calculation of creatinine
clearance, double reciprocal plots,
precision check of internal quality
control results,calculation of various
indices from data obtained during
validation of kits (eg, precision,
accuracy, coefficient of variation,etc)

 



Post Graduate Courses:
·                    M.D Biochemistry
·                    D.C.P
·                    M.D.S

Under Graduate Courses: 
·                    M.B.B.S
·                    B.D.S.
·                    B.Sc.Nursing
·                    B.Sc Cardio Pulmonary Perfusion Technology
·                    B.ScAnaesthesia Technology
·                    B.Sc Optometry
 
Diploma & Certificate courses:
·                    D.M.L.T
·                    DMRSC
And
·                    PhD  
·                    M.Phil Clinical Psychiatry
Periodic academic activities held in the department:
POST GRADUATE:
·                     The Postgraduate students attend Lectures & practical classes taken by the faculty of the Institute during the first year of their along with I M.B.B.S. students.
·                     During the second year of their study, they are actively involved in performing routine biochemical investigations and special tests in analytical lab.
·                     During the third year of the study, they complete their dissertation study.
Seminars, Short topic presentation & Journal Clubs
·                     The department conducts Weekly Journal Clubs analyzing a particular Journal Topic related to clinical biochemistry presented by a post graduate student and moderated by a faculty of the department.
·                     The department involves postgraduate students in Weekly Seminars, Short topic discussions and encourage them to participate in national conferences to present short title papers in national conferences.
Maintenance of Log Book:
·                     Every Post-graduate student maintains a log book as a record of skills acquired during the training period, including training undergone outside the institution. Which is periodically scrutinized by the Director & Head of the Institute and certified at the time of University examinations. The Log Book is submitted at the time of University practical examination for the scrutiny by the Board of Examiners.
·                     PG students regularly participate in the teaching and training programme of post-graduate and intern-students.
Dissertation:
·                     All post graduate students, as part of the curriculum, are assigned a topic of clinical interest for dissertation by the Director in order to learn, design, conduct research studies, interpret data and perform statistical analysis of data . A Professor supervises and guides the PG student to see that the dissertations are done properly by utilizing the clinical materials of the Govt. General Hospital, Chennai.
·                     No marks are given for the dissertation in the university examination and the Board of Examiners mark whether the dissertation either “Approved” or “Not Approved”.
UNDER GRADUATE:
Teaching Methodology
 
o        Lectures,
o        Tutorials,
o        Small group discussions,
o        Integrated teaching modules,
o        Use of charts (paper-based clinical scenarios) for case discussions,
o        Practical exercises &
o        Demonstrations
 
PRIZES & AWARD:
Col.Von Geyzal Prize examination:
 
The department conducts a prize examination for 1st M.B.B.S. students in the subject of biochemistry (theory paper only) at the end of the academic every year and awards prizes.
The student who scores the highest mark in the prize examination is given the coveted Col. Von Geyzal Prize.
The students who score the second & third highest marks in the prize examination are given I Certificate of Honour& II Certificate of Honour respectively during Annual College Day Celebrations.



List of Winners of Prize Examination
  
Year Name of Prize /Medal Awardee
1987-1988 Von Geyzal Prize S. Sampath
  I Certificate of Honour N.Uma
  II Certificate of Honour V.Sridhar
1988 – 89 Von Geyzal Prize N.lakshmi
  I Certificate of Honour TheodareAnbu
  II Certificate of Honour Not awarded
1989-1990 Von Geyzal Prize Sabapathy Prakash
  I Certificate of Honour VeenaRamanai
  II Certificate of Honour ShobaShalini
1990-1991 Von Geyzal Prize V.V.Meera
  I Certificate of Honour V.Vasumathy
  II Certificate of Honour SubhaSundaram
1991-1992 Von Geyzal Prize None Eligible & Not awarded
  I Certificate of Honour None Eligible & Not awarded
  II Certificate of Honour None Eligible & Not awarded
1992-1993 Von Geyzal Prize S.Ramkumar
  I Certificate of Honour DeepaDoraisamy
  II Certificate of Honour K.L.Karthik
1993-1994 Von Geyzal Prize None Eligible & Not awarded
  I Certificate of Honour None Eligible & Not awarded
  II Certificate of Honour None Eligible & Not awarded
1994-1995 Von Geyzal Prize None Appeared for exam
  I Certificate of Honour
  II Certificate of Honour
1995-1996 Von Geyzal Prize G.Rajarajan
  I Certificate of Honour Srimathy
  II Certificate of Honour Deepa
1996-1997 Von Geyzal Prize None Eligible & Not awarded
  I Certificate of Honour V.Prasanna Kumar
  II Certificate of Honour None Eligible & Not awarded
1997-1998 Von Geyzal Prize Not awarded
  I Certificate of Honour Lakshmi Srinivasan
  II Certificate of Honour Not awarded
1998-1999 Von Geyzal Prize Not awarded
  I Certificate of Honour J.Murali
  II Certificate of Honour K.Srikanth
1999-2000 Von Geyzal Prize Murali Krishnan
  I Certificate of Honour Manish Kiran
  II Certificate of Honour Mohamed Yunus
2000-2001 Von Geyzal Prize V.Jayaprakash
  I Certificate of Honour R.M.Subramaniam
  II Certificate of Honour None Eligible & Not awarded
2001-2002 Von Geyzal Prize None Eligible & Not awarded
  I Certificate of Honour None Eligible & Not awarded
  II Certificate of Honour None Eligible & Not awarded
2002-2003 Von Geyzal Prize S.Suresh
  I Certificate of Honour k.Srinivasan
  II Certificate of Honour K.Arvind
2003-2004 Von Geyzal Prize B.P.Krishna Prasad
  I Certificate of Honour R.Balaji
  I Certificate of Honour C.Pradeep
2004-2005 Von Geyzal Prize Deepika
  I Certificate of Honour Liza Das
  II Certificate of Honour IpshitaKak
2005-2006 Von Geyzal Prize Not awarded
  I Certificate of Honour S.Yamini
  II Certificate of Honour PoornimaSankar
2006-2007 Von Geyzal Prize Harshvardhan
  I Certificate of Honour Vivek Sandeep
  II Certificate of Honour Sandhya Suresh
2007-2008 Von Geyzal Prize RakeshDurai
  I Certificate of Honour Kathikeyan
  II Certificate of Honour Hariharan
2008-2009 Von Geyzal Prize Rupesh Kumar
  I Certificate of Honour H.Naren
  II Certificate of Honour PL.Vidya
2009-10 Von Geyzal Prize  
  I Certificate of Honour  
  II Certificate of Honour  
2010-2011 Von Geyzal Prize None Eligible & Not awarded
  I Certificate of Honour R.Sathyasagar
  II Certificate of Honour  
2011-2012 Von Geyzal Prize R.Sangeetha
  I Certificate of Honour S.Joel Kevin Raj
  II Certificate of Honour  
2012-2013 Von Geyzal Prize Aaashish Rajesh
  I Certificate of Honour  
2013-2014 Von Geyzal Prize Maamannan.V.J
  I Certificate of Honour Krupasankari.S
2014-2015 Von Geyzal Prize AakanshaAjith
  I Certificate of Honour Divya. V
2015-2016 Von Geyzal Prize Akashvenkatram
  I Certificate of Honour Gokuldev
2016-2017 Von Geyzal Prize M.Mouhnish Darshan
  I Certificate of Honour S.Karthika
 
CME. WORKSHOP
 
S.NO DATE   TOPIC
  20.06.2015 WORKSHOP Capillary Electrophoresis
  30.07.2015
 
31.07.2015
 
01.08.2015
STATE CONFERENCE OF AMBI Ambi-TamilNadu National Conference- Quality
Management and Automation in Clinical
Chemistry Laboratory- Essentials and Beyond
 30 CREDIT POINTS
  26.05.2016 WORKSHOP Training on Laboratory Equipments
  4.6.16 CME Nephelometry & its Application in Clinical
Diagnosis
   
17.6.16 &
18.6.16
WORKSHOP Safe blood collection practices.
  23.07.2016 GUEST LECTURE  
Haemoglobinopathies
 
   
25.07.16
 
GUEST LECTURE
by DR.MARGRET
 
Approach to Hemolytic Anemias
   
14.02.17
 
GUEST LECTURE
by DR. PAVAI
 
Approach to Vitamin B12 Deficiency
   
03.03.17
 
CME
Approaches & Challenges In Diagnosis of Lysosomal Storage Disorders In India
   
27.05.17
 
CME
 
Hypovitaminosis D- Myth Or Reality
   
13.06.17
 
WORKSHOP
 
Capillary Electrophoresis
   
03.07.17
&
04.07.17
 
 
WORKSHOP
SDS-PAGE Electrophoresis,
Submarine Electrophoresis,
Western Blotting
& Gel Documentation
   
10.07.17
 
SEMINAR
 
Interpretation of Serum Protein Electrophoresis
   
25.07.17
26.07.17
27.07.17
28.07.17
 
 
WORKSHOP
 
Laboratory Quality Management System and
Internal Audit as per ISO15189:2012
30 CREDIT POINTS
  23.12.17 WORKSHOP Column Chromatopgraphy for Vanilmandelic
acid, Metanephrines.
  22.12.17 WORKSHOP Isoelectric focusing for Lipoprotein
17. 1.2.18 WORKSHOP Isoelectric focusing for Protein
 
 
ONGOING RESEARCH:
·                     A study on iron status and thyroid function: mutual realtionship in hypothyroidism. Dr.K.S.Gokilaveni.
·                     Mannose binding lectin as a diagnostic marker for coronary artery disease in hypertensive patients. Dr.M.Dilagamari.
·                     Serum soluble alpha-klotho and FGF-23 levels in chronic kidney disease. Dr.D.Kalpana.
·                     A study of osteoprotegerin as a predictor of myocardial infarction in Type II Diabetes Mellitus patients. Dr.Niveditha Devi Rajendran.
·                     Urinary Kidney Injury Molecule (KIM-1), a marker of acute kidney injury in renal transplant patients. Dr.R.P.Vinodkumar.
·                     Soluble transferrin receptor –ferritin index in the diagnosis of anaemia of chronic disease in patients with rheumatoid arthritis. Dr.M.V.Preethi.
·                     Correlation of immunoglobulin free light chains on risk stratification in chronic obstructive pulmonary disease patients. Dr.R.Geethanjali.
·                     Study on the congenital disorders of glycosylation in patients with neurodegenerative features. Dr.K.Ramadevi.
·                     A Study of serum electrophoresis pattern by capillary electrophoresis in chronic renal failure cases. Dr.R.P.Vinodkumar
·                     A Study of serum electrophoresis pattern by capillary electrophoresis in liver diseases. Dr.Preethi,
·                     A Study of serum electrophoresis pattern by capillary electrophoresis in plasma cell disorders and various inflammatory conditions.Dr.R.Geethanjali.
·                     AST/ALT ratio and LFT in CCF patients. Dr.Preethi,
·                     A study on Characteristics of anaemia in Subclinical and Overt Hypothyroidism.,ICMR project by student - Anand prakash.
·                     A study on Non alcoholic fatty liver Disease., ICMR project by student - Kishore Shankar.
·                     Study of chronic renal failure and its significance  on the population Ms.C.SangeethaDayanidhi, PhD scholar ,paper approved.
§     Susceptibility of diabetes with superoxide dismutase 2 gene polymorphism to vascular complications. Dr.A.C.Archana.
RESEARCH CONDUCTED IN LAST 5 YEARS
§     Association of osteopontin 9250 SNP with SLE. Dr.V.Yogeswari.
§     Association of MMP-2 gene polymorphism with MI. Dr.B.SudhaPresanna.
§     Association of leptin gene polymorphism in essential HT. Dr.M.Subarathi
§     Neutrophil Gelatinase Associated Lipocalin(NGAL)an early marker for Diabetic Nephropathy. Dr.A.Shameem
§     The levels of Galectin -3 and B-  type natriureticpeptide in chronic heart failure. Dr.Kathija.B
§     Association of endothelial lipase gene (LIPG 584C>A) polymorphism with HDL Cholesterol and its subfraction in response to exercise training. Dr.D.Vinothkumar
§     A study on altered total plasma homocysteine level and lipid profile in newly diagnosed hypothyroid individuals. Dr.P.Renuka
§     Serum prolactin levels in recently diagnosed rheumatoid arthritis. Dr.M.Karthiga
§     Evaluation of 25-OH vitamin D in type 2 diabetes mellitus patients with and without nephropathy. Dr.P.Deepa
§     A study on thyroid function status in newly diagnosed polycyctic ovarian syndrome patients. Dr.AmrithaJancy Rani
§     Retraction transaminitis – a benign complication of laprotomy. Dr.AmrithaJancy Rani
§     A case report of vitamin D resistant rickets. Dr.P.Renuka
§     Correlation of Plasma Osteopontin with radiological grading in patients with osteoarthritis in knee joint. Dr.P.Nirmaladevi
§     Role of Uric acid and hsCRP as a renal and cardiovascular risk markers 2in type1diabetes mellitus with low GFR .Dr.S.Anandhi
§     Significance of CTLA4 gene (cytotoxic T-lymphocyte associated protein,49A>G) polymorphism in SLE. Dr.M.Divya
§     S.Leptin. levels in Rheumatoid arthritis. Dr. Michael Rajam Geetha
§     A study on Glcosylation pattern of Serum Transferrin in patients with clinically suspected Congenital Glycosylation disorders. Dr.A.Preethi.
§     A study on Plasma Adiponectin level and its correlation with Lipid Profile in newly diagnosed Hypothyroid and Hyperthyroid individuals. Dr.V.Priyadharsini
§     Evaluation of Serum Cytokeratin 18m30 levels in cases of Non Alcoholic Fatty Liver Disease. Dr.J.Vinodha
§     Biomarkers in chronic obstructive pulmonary disease. Dr.S.Sumathy
§     G6PD deficiency in children in developmental delay. Dr.Amudhavalli
§     A case report on Hypertriglyceridemia induced acute Pancreatitis and the role of Laboratory Investigations. Dr.G.Chitrasivasankari
§     Serum Transaminases level in rodenticide Poisoning. Dr.R.Gayathri
§     Determination of Bilirubin Interference in Creatinine Assay by Jaffe’s     
§     method among Chronic kidney Disease patients.Dr.T.Poornima
§     Serum Gamma –glutamyl transferase levels in Coronary artery Disease patients. Dr.A.K.Roopa
 
§     PhD
§     Biochemical and clinical characterization of Iodine deficiency disorders in Tamilnadu. Mr .P.Suresh-PhD Research scholar.
 
POST GRADUATE LIST
2017 BATCH
Dr. R.P.VINOD KUMAR                                
Dr. M.V.PREETHI                                            
Dr. R.GEETHANJALI      
2016 BATCH
Dr. KALPANA.D
Dr. DILAGAMARI.M
Dr. K.S.GOKILAVENI                                       
Dr. NIVEDITHA DEVI RAJENDRAN               
2015 BATCH
Dr. CHITRA SIVA SANKARI.G
Dr. GAYATHRI. R                                             
Dr. POORNIMA.T
Dr. ROOPA. A. K.                                              
 
RESEARCH PUBLICATIONS IN LAST 5 YEARS
·                     Excess urinary iodine excretion on pregnant women with or without thyroid disorder in Tamilnadu. Dr.K.Ramadevi, International journal of clinical biochemistry and research. Dec 2017,Vol.5,Issue.2.
·                     Serum Uric acid levels in chronic obstructive lung disease patients – Dr.S.Sumathy. International Journal of scientific research Volume 6.Issue 5.May 2017
·                     Association of cyclooxygenase 2 gene polymorphism in irritable bowel syndrome Dr.S.Siva- Scholars Journal of Applied Medical Sciences. Aug 2017.
·                      Association of CYP17 gene polymorphism with carcinoma of Prostate- Dr.S.Siva , Scholars Journal of Applied Medical Sciences. Aug 2017.
·                     Hyperprolactinemia in Systemic Lupus Erythematosus – Dr.K.Menaka Shanthi. International journal of current microbiology and applied sciences Volume 6,number 5(2017) pp.2788-2792
·                     A study on Lipoprotein (a) levels in atherosclerotic peripheral arterial disease Dr. A. Veena Juliette – Scholars Journal of Applied Medical Sciences. March 2017,5(3A),744-748
·                     A Case Control study on the Association of Transforming growth Factor- β with Atherosclerosis. Dr.A. Veena Juliette Scholars Journal of Applied Medical Sciences (SJAMS),2017;5(8D);3222-3227 .
·                     Association of Cholesteryl Ester transfer protein with severity of angiographically confirmed Coronary Artery Disease – Dr.A. Veena Juliette National journal of basic medical science. Volume 7, Issue 3, 2017.
·                     Plasma fibrinogen in essential hypertention- Dr.V.Yogeswari, Scholars Journal of Applied Medical Sciences (SJAMS). Issue 8,Aug 2017
·                     Association of osteopontin gene single nucleotide polymorphism with systemic lupus erythematosus- Dr.V.Yogeswari,International journal of clinical biochemistry and reseasrch Volume 4,Issue 4,2017
·                     Developmental Delay and Mental Retardation in patients with Inherited metabolic disorders, Dr.K.Ramadevi , Int.J of Pharma and Biosciences, 2016 July ; 7(3): (B) 1005 – 1008
·                     Analytical sensitivity of TSH assays by ELISA and ELFA Dr.K.Pramila– National Journal of Basic Medical Sciences | Volume 6 | Issue 4 |  june2016
·                     The role of high sensitivity C-Reactive protein as a cardiovascular risk marker in Essential Hypertension- Dr.K.Pramila Journal of Medical Sciences and Health/May-Aug 2016/Volume 2/Issue 2 .
·                     Hyperprolactinemia in elderly patients with osteoporosis – Dr.S.Sumathy
National Journal of basic medical science.volume 7-issue 1-Sep 2016
·                     Role of plasma fibrinogen as a biomarker in chronic obstructive pulmonary disease – Dr.S.Sumathy Scholars Journal of Applied Medical Sciences. july 2016  
·                     The Role of Intra-Operative Parathyroid Hormone Estimation in the Surgical Management of Patient with Parathyroid Adenoma- A Case Report – Dr.S.Sumathy, Scholars Journal of Medical Case Reports 2016; 4(9):641-643
·                      Thyroid profile in patients with breast tumoursDr.S.Sumathy International journal for Pharma and Bioscience– Oct 2016
·                     Role of Micronutrient Zinc in Pulmonary Tuberculosis, Dr.C.Mythili, Scholars Journal of Applied Medical Sciences (SJAMS) Sch. J. App. Med. Sci., 2016; 4(5A):1519-1524.    
·                      Preparation of Chitosan/Seaweed-ZnO nanorods for better anti bacterial  Activity – Dr.S.Siva IJCTA, 9(9), 2016, pp. 4003-4008.sep 2016
·                      A Smart Heart Rate Sensing System in the Internet of Things Dr.S.Siva IJCTA, 9(9), 2016, pp. 3659-3663. – sep 2016.
·                      Angiotensin Converting Enzyme (ACE) gene insertion deletion polymorphism and its association with Type 2 Diabetic Nephropathy – Dr.K.Menaka Shanthi National journal of basic medical science Volume 6.Issue 3. 2016.
·                      Analytical sensitivity of TSH assays by ELISA and ELFA. Dr.K.Menaka Shanthi National journal of basic medical science.2016.
·                     Association of Matrix Metalloproteinase-2 Gene Promoter Polymorphism and the Associated Phenotype Variation with Myocardial Infarction – Dr.B.SudhaPresanna, Scholars Journal of Applied Medical Sciences (SJAMS). Sch. J. App. Med. Sci., 2016; 4(7B):2417-2422.
·                      Association of CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia –Dr. V.Ananthan, Scholars Journal of Applied Medical Sciences (SJAMS). Sch. J. App. Med. Sci., 2016; 4(7E):2630-2635
·                     12 Novel HGD gene mutations identified in 99 Alkaptonuria patients:Focus on “Black Bone disease”  in Italy , Dr.K.Ramadevi ,–- European Journal of Human Genetics 24(1), March 2015
·                     A rare case of glycine encephalopathy unveiled by valproate therapy – Dr.K.Pramila , J PediatrNeurosci. 2015 Apr-Jun; 10(2): 143–145.
·                     Serum Cystatin C and Microalbumin in the detection of early Nephropathy in Type II Diabetic patients,Dr.K.Ramadevi ,Int J Phama Bio Sci 2015 April:6(2): (B) 1208- 1214
·                     Iodine Excess and Thyroid dysfunction. Dr.K.Ramadevi ,Journal of International Medical Sciences Academy, April-June 2015, Vol 28, No.1, 83-85.
·                     Diagnostic Value of Ferroxidase Activity of Ceruloplasmin in Extra PulmonaryTuberculosis, Dr.C.Mythili,Scholars Journal of Applied Medical Sciences (SJAMS) Sch. J. App. Med. Sci., 2015; 3(2F):919-921
·                     Serum Peroxinase Activity in CKD NJBMS   Dr.K.Pramila- NJBMS April –June 2014
 
SERVICES OFFERED:
List of Laboratory tests performed
 
BIOCHEMISTRY PARAMETERS
S.NO ANALYTE
1 Glucose
2 Urea
3 Creatinine
4 Bilirubin – Total                                                           
5 Bilirubin Direct
6 SGOT
7 SGPT
8 Alkaline phosphatase
9 Total Protein
10 Albumin
11 Sodium
12 Potassium
13 Chloride
14 T. Cholesterol
15 Triglyceride
16 HDL
17  LDL                                                                                                                               
18 Iron
19 Uric acid                                                                                                                          
20 Amylase
21  Lipase
22 Calcium
23 Phosphorus
24 CK                                                                                                                       
25 CKMB                                                                                                                              
26 LDH
27 Lactate
28 Ammonia
29 HbA1C
30 Homocysteine
31 CRP
32 Magnesium
33 Ceruloplasmin
34 Microprotein
35 Free light chains- Kappa
36 Free light chains- Lambda
 
HORMONES AND DRUGS (IMMUNOASSAY)
 
S.No ANALYTE
1 AFP
2 B12
3 Cortisol
4 c- Peptide
5 Ferritin
6 Folate
7 Free PSA%
8 FSH
9 fT4
10 TSH
11 fT3
12 GH
13 LH
14 Prolactin
15 PTH
16 Total PSA
17 Troponin T hs
18 Vitamin D (Total)
19 CA125
20 CEA
21 ACTH
22 DHEAS
23 Testosterone
24 Procalcitonin
25 Thyroglobulin
 
 
STONE ANALYSIS
1 Urinary stones
2 Gall stones
3 Others- Pancreatic and salivary
ARTERIAL BLOOD GAS ANALYSIS
 
1 pH
2 pO2
3 pCO2
4 HCO3 calculated
5 Anion Gap
6 Hct
 
  URINE ANALYSIS- Quantitative
 
  URINE ANALYSIS-
Qualitative
1 pH 1 BJP
2 Specific gravity 2 Urobilinogen/ Porphobilinogen
3 Protein 3 VanillylMandelic Acid (VMA)
4 Protein Creatinine Ratio    
5 Sodium    
6 Uric Acid    
7 Calcium    
 
OTHER FLUID ANALYSIS
 
  CSF   Pleural/ Ascitic Fluid
1 Glucose 1 Glucose
2 Protein 2 Protein
3 LDH 3 LDH
    4 Amylase
    5 Lipase
 
 
 
 
 
  OTHER SPECIAL TESTS
1 Serum Protein Electrophoresis
2 Serum Protein electrophoresis & Immunofixation
3 SDS Page with Western Blotting and Gel Documentation
4 Isoelectric focusing for special proteins
5 Gene polymorphism by Polymerised Chain Reaction
6 Column chromatography-
1.                 Metanephrine
2.                 17 Keto-steroids
3.                 5-OH Indole acetic acid
4.                 Vanillylmandelic acid (VMA)
5.                 17-OH Corticosteroids
6.                 Aminolevulinic acid(ALA)
7.                 Porphobilinogen
 
 
Total number of tests done: 103
All the following six institutions attached to Madras Medical College & Government General Hospital have separate biochemistry department & service laboratories which caters to the need of their patients which is supervised by qualified personnel.
·                     Institute of Child Health & Hospital for Children, Egmore Chennai - 8
·                     Institute of Obstetrics &Gynaecology, Egmore Chennai – 8
·                     Regional Institute of Ophthalmology & Govt. Ophthalmic Hospital, Egmore. Chennai - 8
·                     Institute of Mental Health, Ayyanavaram. Chennai - 23
·                     Kasturba Gandhi Hospital for Women & Children, Triplicane. Chennai -5
Laboratory Statistics (average tests conducted / annum):
Laboratory Statistics 2017:  2509415 tests.
 








































































CME, WORKSHOP & CONFERENCE LIST JAN 2015-JUNE 2016
 

 
 
S.NO DATE                                 TOPIC
1. 20.06.2015 WORKSHOP CAPILLARY ELECTROPHORESIS
2. 30.07.2015
 
31.07.2015
 
01.08.2015
NATIONAL
 
CONFERENCE
AMBI- TN NATIONAL CONFERENCE-
 
QUALITY MANAGEMNT AND AUTOMATION IN CLINICAL
 
CHEMISTRY LABORATORY- ESSENTIALS AND BEYOND

 
4. 26.05.2016 WORKSHOP TRAINING ON LABORATORY EQUIPMENTS
5 4.6.16 CME NEPHELOMETRY & ITS APPLICATION IN CLINICAL DIAGNOSIS
6 17.6.16  & 18.6.16 WORKSHOP SAFE BLOOD COLLECTION PRACTICES.
7 23.07.2016 GUEST LECTURE HAEMOGLOBINOPATHIES

 
 
LIST OF ONGOING EVENTS:

 
S.NO DATE                                   TOPIC
1. 20.08.16 GUEST LECTURE DR.I.PERIAYNDAVAR
 
PROF OF DIABETOLOGY
DIABETES MELLITUS OVERVIEW
 
RESEARCH PUBLICATIONS:
S.No Author & Co authors Title  of  Article Name  of the  Journal Year &   Month
1 Dr.K.Ramadevi Hypothyroid Goitre Associated with excess Iodine among south Indians. Int.J of Medl Pharm Sci Jan 2014, Vol 4(5) 23-31.
 
    Serum Cystatin C and Microalbumin in the detection of early Nephropathy in Type II Diabetic patients Int J Phama Bio Sci 2015 April:6(2): (B) 1208- 1214.
 
    12 Novel HGD gene mutations identified in 99 Alkaptonuria patients:Focus on “Black Bone disease”  in Italy. European Journal of Human Genetics 
 
 24(1), March 2015
 
    Iodine Excess and Thyroid dysfunction. Journal of International Medical Sciences Academy. April-June2015, Vol 28, No.1, 83-85
 
    Thyromegaly  and  iodine Nutritional  status  in  a Tertiary  care  hospital  in South  Indian. Indian J Endocr Metab.
 
2016 December.
 
    Developmental Delay and Mental Retardation in patients with Inherited metabolic disorders. Int.J of Pharma and Biosciences.  2016 July ; 7(3): (B) 1005 - 1008
 
2 Dr Pramila .K Serum Paraoxonase activity in chronic kidney disease. National Journal of Basic Medical Sciences. 2014 June.
 
    The  role  of  high sensitivity C-reactive  protein  as  a cardio vascular  risk marker  in  Essential hypertension . Journal  of  Medical Sciences  and Health. 2016 August.
 
    Analytical sensitivity of TSH assays by ELISA and ELFA. National journal of basic medical science. Volume 6.Issue 4. 2016.
 
3 Dr.S.Sumathy
 
Hyperprolactinemia in elderly patients with osteoporosis. Journal of basic medical science. September 2106.
    Role of plasma fibrinogen as a biomarker in chronic obstructive pulmonary disease. Scholars Journal of Applied Medical Sciences. July 2016.
 
    Thyroid profile in patients with breast carcinoma. International journal for Pharma and Bioscience.  
October 2016.

 
    Association of Matrix Metalloproteinase-2 Gene Promoter Polymorphism and the Associated Phenotype Variation with Myocardial Infarction. Scholars Journal of Applied Medical Sciences. 
 
 
July 2016.

 
4 Dr. V. Ananthan
 
Association of CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia. Scholars Journal of Applied Medical Sciences (SJAMS). Sch. J. App. Med. Sci., 2016; 4(7E):2630-2635.
    Association of Matrix Metalloproteinase-2 Gene Promoter Polymorphism and the Associated Phenotype Variation with Myocardial Infarction. Scholars Journal of Applied Medical Sciences (SJAMS). Sch. J. App. Med. Sci., 2016; 4(7B):2417-2422.
5 Dr.C.Mythili
 
Diagnostic value of ferroxidase activity of ceruloplasmin in extra pulmonary tuberculosis. Scholars Journal of Applied Medical Sciences. 2015 March.
 
    Role of micronutrient zinc pulmonary tuberculosis. Scholars Journal of Applied Medical Sciences. 2016 May.
 
6 Dr.V.G.Karpaghavalli
 
Thyroid profile in patients with breast carcinoma. International journal for Pharma and Bioscience. October 2016.
 
    Hyperprolactinemia in elderly patients with osteoporosis. Journal of basic medical science. September 2106.
 
    Role of plasma fibrinogen as a biomarker in chronic obstructive pulmonary disease. Scholars Journal of Applied Medical Sciences. July 2016.
 
7 Dr.S.Siva
 
Preparation of Chitosan/Seaweed-ZnO nanorods for better Antibacterial activity. IJCTA, 9(9), 2016, pp. 4003-4008. IJCTA, 9(9), 2016, pp. 4003-4008.
    A Smart Heart Rate Sensing System in the Internet of Things. IJCTA, 9(9), 2016, pp. 3659-3663.
 
IJCTA, 9(9), 2016, pp. 3659-3663.
 
8 Dr.Menaka Shanthi
 
Angiotensin converting enzyme gene insertion deletion polymorphism and its association with type 2 diabetic nephropathy. National journal of basic medical science. National journal of basic medical science.
 
Volume 6.Issue 3. 2016.
    Analytical sensitivity of TSH assays by ELISA and ELFA. National journal of basic medical science. Volume 6.Issue 4. 2016.
 
9 Dr. B. Sudhapresanna Association of Matrix Metalloproteinase-2 Gene Promoter Polymorphism and the Associated Phenotype Variation with Myocardial Infarction. Scholars Journal of Applied Medical Sciences (SJAMS). Sch. J. App. Med. Sci., 2016; 4(7B):2417-2422.
    Association of CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia. Scholars Journal of Applied Medical Sciences (SJAMS). Sch. J. App. Med. Sci., 2016; 4(7E):2630-2635.
 
 
 
Services Offered:
 
 List of Laboratory tests performed
S.No Test Name
1 Glucose
2 Urea
3 Creatinine
4 Bilirubin - Total                                                           
5 Bilirubin – Direct
6 SGOT
7 SGPT
8 Alkaline Phosphatase
9 Total Protein
10 Albumin
11 Sodium
12 Potassium
13 Chloride
14 T. Cholesterol
15 Triglyceride
16 HDL
17 LDL                                                                                                                              
18 Uric acid                                                                                                                          
19 Amylase
20 Lipase
21 Calcium
22 Phosphorus
23 Magnesium 
24 Iron                                                                                                                      
25 CK                                                                                                                             
26 CKMB
27 LDH
28 Lactate
29 Ammonia
30 HbA1C
31 Homocysteine
32 CRP
33 Ceruloplasmin
34 Microprotein
35 Free light chains- Kappa
36 Free light chains- Lambda
Hormones (Immunoassay)
1 fT3
2 fT4
3 TSH
4 Cortisol
5 C- Peptide
6 FSH
7 LH
8 GH
9 Prolactin
10 PTH
11 ACTH
12 DHEAS
13 Testosterone
14 Procalcitonin
15 Thyroglobulin
Cardiac Markers
1 Troponin T hs
Vitamins
1 B12
2 Ferritin
3 Folate
4 Vitamin D (Total)
Tumour Markers
1 AFP
2 CA125
3 CEA
4 Total PSA
5 Free PSA%
Therapeutic Drug Monitoring
1 Lithium
2 Valproate
3 Phenytoin
4 Phenobarbitone
Arterial Blood Gas Analysis
1 pH
2 pO2
3 pCO2
4 HCO3 calculated
5 Anion Gap
6 Hct
Other Body Fluid Analysis
CSF:
1 Glucose
2 Protein
3 LDH
Pleural/ Ascitic Fluid:
1 Glucose
2 Protein
3 LDH
4 Amylase
5 Lipase
Stone Analysis
1 Urinary stones
2 Gall stones
3 Others- Pancreatic and salivary
Other Special Tests
1 Serum Protein Electrophoresis
Urine Analysis- Quantitative
1 pH
2 Specific Gravity
3 Protein
4 Protein Creatinine Ratio
5 Sodium
6 Uric Acid
7 Calcium
8 Creatinine Clearance
Urine Analysis- Qualitative
1 BJP
2 Urobilinogen/ Porphobilinogen
3 Vanillyl Mandelic Acid (VMA)
 :

























































































































Total number of tests done: 95

All the following six institutions attached to Madras Medical College & Government General Hospital have separate biochemistry department & service laboratories which caters to the need of their patients which is supervised by qualified personnel.
  • Institute of Child Health & Hospital for Children, Egmore Chennai - 8
  • Institute of Obstetrics & Gynaecology, Egmore Chennai – 8
  • Institute of Child Health & Hospital for Children , Egmore Chennai - 8
  • Regional Institute of Ophthalmology & Govt. Ophthalmic Hospital, Egmore. Chennai - 8
  • Institute of Mental Health, Ayyanavaram. Chennai - 23
  • Kasturba Gandhi Hospital for Women & Children, Triplicane. Chennai - 5
  • Average laboratory statistics (average tests conducted / annum)
Laboratory Statistics (average tests conducted / annum):
Laboratory Statistics 2016:  2786142 Tests.
 

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